Article
Pharmacogenomics in thrombosis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Mousa Shaker A
Abstract excerpt
Inherited or acquired genetic abnormalities play a major role in thromboembolic complications. The goal of pharmacogenomics is to tailor medications to an individual's genetic makeup in order to improve the benefit-to-risk ratio. Significant findings have been documented showing the effect of certain genetic variations (e.g., in CYP2C9 and VKORC1) on the dose response to warfarin. Pharmacogenomic and genetic...
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