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Article

Inherited variations in AR, ESR1, and ESR2 genes are not associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2010

Sun Tong, Lee Gwo-Shu Mary, Werner Lillian, Pomerantz Mark, Oh William K, Kantoff Philip W, Freedman Matthew L

Abstract excerpt

BACKGROUND: Sex steroid hormone receptors mediate essential processes in normal prostate growth and contribute to prostate cancer development. METHOD: In this study, we investigated the association between common inherited variation of the AR, ESR1, and ESR2 genes and two clinically relevant traits: the risk of developing aggressive prostate cancer and the response to androgen deprivation therapy (ADT) in a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20615892
DOI: 10.1158/1055-9965.EPI-10-0216
PMCID: PMC3755451

Genes

ESR1
ESR2
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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