Efficient computation of patterned covariance matrix mixed models in quantitative segregation analysis.

Abstract excerpt

The use of patterned covariance matrices in forming pedigree-based mixed models for quantitative traits is discussed. It is suggested that patterned covariance matrix models provide intuitive, theoretically appealing, and flexible genetic modeling devices for pedigree data. It is suggested further that the very great computational burden assumed in the implementation of covariance matrix-dependent mixed models...

Topics

• Algorithms
• Computers
• Epidemiologic Methods
• Genetic Markers
• Humans
• Models, Genetic
• Multivariate Analysis
• Normal Distribution
• Phenotype