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Article

Analysis of RuvABC and RecG involvement in the escherichia coli response to the covalent topoisomerase-DNA complex.

Journal of bacteriology - 1 Sept 2010

Sutherland Jeanette H, Tse-Dinh Yuk-Ching

Abstract excerpt

Topoisomerases form a covalent enzyme-DNA intermediate after initial DNA cleavage. Trapping of the cleavage complex formed by type IIA topoisomerases initiates the bactericidal action of fluoroquinolones. It should be possible also to identify novel antibacterial lead compounds that act with a similar mechanism on type IA bacterial topoisomerases. The cellular response and repair pathways for trapped...

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Source

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Identifiers

PMID: 20601468
DOI: 10.1128/JB.00350-10
PMCID: PMC2937393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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