Myelodysplastic Syndromes Arising in Patients With Germline <i>TP53</i> Mutation and Li-Fraumeni Syndrome

Abstract excerpt

Abstract Context.—Li-Fraumeni syndrome (LFS), characterized by predisposition to early onset of a variety of malignancies, is usually associated with germline mutation of the tumor-suppressor gene, TP53. Mutation carriers are at increased risk of multiple primary tumors, many of which arise in previous radiation-therapy sites. In patients with LFS, acute myeloid leukemia is uncommon and myelodysplastic syndrome...

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