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A Genome-Wide Profiling of the Humoral Immune Response to <i>Chlamydia trachomatis</i> Infection Reveals Vaccine Candidate Antigens Expressed in Humans

26 Jun 2010

Abstract excerpt

A whole genome scale proteome array consisting of 908 open reading frames encoded in Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab responses. A total of 719 chlamydial proteins was recognized by one or more antisera from 99 women urogenitally infected with C. trachomatis. Revealing such a large C. trachomatis ANTIGENome in humans might partially be attributed to the significantly...

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PMID: 20581152
DOI: 10.4049/jimmunol.1001240

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