Identification of Immunodominant Antigens by Probing a WholeChlamydia trachomatisOpen Reading Frame Proteome Microarray Using Sera from Immunized Mice

Abstract excerpt

Chlamydia trachomatis infections can lead to severe chronic complications, including trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is vaccination. The goal of this work was to identify new potential vaccine candidates through a proteomics approach. We constructed a protein chip array (Antigen Discovery, Inc.) by expressing the open reading frames (ORFs) from C....

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