Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear Role of WASp in the Pathogenesis of Dysregulated T <sub>H</sub> 1 Immunity in Human Wiskott-Aldrich Syndrome

23 Jun 2010

Abstract excerpt

The clinical symptomatology in the X-linked Wiskott-Aldrich syndrome (WAS), a combined immunodeficiency and autoimmune disease resulting from WAS protein (WASp) deficiency, reflects the underlying coexistence of an impaired T helper 1 (TH1) immunity alongside intact TH2 immunity. This suggests a role for WASp in patterning T(H) subtype immunity, yet the molecular basis for the TH1-TH2 imbalance in human WAS is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20574068
DOI: 10.1126/scitranslmed.3000813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear Role of WASp in the Pathogenesis of Dysregulated T <sub>H</sub> 1 Immunity in Human Wiskott-Aldrich SyndromePMID 20574068Read ↗

SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells.Semantic proximity Read ↗

Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Wiskott‐Aldrich syndrome protein: Emerging mechanisms in immunitySemantic proximity Read ↗

Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Wiskott–Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseasesSemantic proximity Read ↗

Cellular functions of WASP family proteins at a glanceSemantic proximity Read ↗

Clinical spectrum, pathophysiology and treatment of the Wiskott–Aldrich syndromeSemantic proximity Read ↗

The Wiskott-Aldrich syndrome.Semantic proximity Read ↗

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cellsSemantic proximity Read ↗

Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation.Semantic proximity Read ↗

Wiskott–Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humansSemantic proximity Read ↗

Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.