Article
Milroy's primary congenital lymphedema in a male infant and review of the literature.
In vivo (Athens, Greece) - 1 Jan 2000
Kitsiou-Tzeli Sophia, Vrettou Christina, Leze Eleni, Makrythanasis Periklis, Kanavakis Emmanouel, Willems Patrick
Abstract excerpt
BACKGROUND: Milroy's primary congenital lymphedema is a non-syndromic primary lymphedema caused mainly by autosomal dominant mutations in the FLT4 (VEGFR3) gene. Here, we report on a 6-month-old boy with congenital non-syndromic bilateral lymphedema at both feet and tibias, who underwent molecular investigation, consisted of PCR amplification and DHPLC analysis of exons 17-26 of the FLT4 gene. The clinical...
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