Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of glioma's multidrug resistance phenotype on (99m)Tc-tetrofosmin uptake.

Molecular imaging and biology - 1 Apr 2011

Alexiou George A, Goussia Anna, Kyritsis Athanasios P, Tsiouris Spyridon, Ntoulia Antigoni, Malamou-Mitsi Vassiliki, Voulgaris Spyridon, Fotopoulos Andreas D

Abstract excerpt

PURPOSE: Multidrug resistance (MDR) remains a major obstacle to successful chemotherapeutic treatment of cancer. Several chemotherapeutic and radiopharmaceutical agents are substrates of the pumps encoded by the MDR genes, and therefore, their accumulation is prevented. We evaluated in vivo whether [(99m)Tc]tetrofosmin ((99m)Tc-TF) uptake is influenced by the MDR profile of gliomas. PROCEDURES: Eighteen patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Multiple
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Organophosphorus Compounds

Share to Phenotype

Share to Tomography, Emission-Computed, Single-Photon

Source

Identifiers

PMID: 20552283
DOI: 10.1007/s11307-010-0369-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of glioma's multidrug resistance phenotype on (99m)Tc-tetrofosmin uptake.PMID 20552283Read ↗

Study of monoglutathionyl conjugates TC-99M-sestamibi and TC-99M-tetrofosmin transport mediated by the multidrug resistance-associated protein isoform 1 in glioma cells.Semantic proximity Read ↗

Assessment of the in vitro and in vivo properties of a (99m)Tc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein.Semantic proximity Read ↗

Imaging of multidrug resistance in cancer.Semantic proximity Read ↗

Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model.Semantic proximity Read ↗

Clinical imaging of multidrug resistance in cancer.Semantic proximity Read ↗

MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake.Semantic proximity Read ↗

Evidence for a constitutive, verapamil-sensitive, non-P-glycoprotein multidrug resistance phenotype in malignant glioma that is unaltered by radiochemotherapy in vivo.Semantic proximity Read ↗

Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells.Semantic proximity Read ↗

The role of 99mTc-MIBI scintigraphy in the assessment of MDR1 overexpression in patients with musculoskeletal sarcomas: comparison with therapy response.Semantic proximity Read ↗

Expression of P-glycoprotein in human glioma cell lines and surgical glioma specimensSemantic proximity Read ↗

Radiopharmaceuticals for assessing ABC transporters at the blood–brain barrierSemantic proximity Read ↗

TC-99m MIBI SPECT imaging in patients with lung carcinoma: is it a functional probe of multidrug resistance genes?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.