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Article

The copper centers of tyramine β-monooxygenase and its catalytic-site methionine variants: an X-ray absorption study.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Nov 2010

Hess Corinna R, Klinman Judith P, Blackburn Ninian J

Abstract excerpt

Tyramine β-monooxygenase (TBM) is a member of a family of copper monooxygenases containing two noncoupled copper centers, and includes peptidylglycine monooxygenase and dopamine β-monooxygenase. In its Cu(II) form, TBM is coordinated by two to three His residues and one to two non-His O/N ligands consistent with a [Cu(M)(His)(2)(OH(2))(2)-Cu(H)(His)(3)(OH(2))] formulation. Reduction to the Cu(I) state causes a...

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PMID: 20544364
DOI: 10.1007/s00775-010-0677-3
PMCID: PMC2988203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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