Article
Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.
Annals of the New York Academy of Sciences - 1 Jun 2010
Lebel Michel, Massip Laurent, Garand Chantal, Thorin Eric
Abstract excerpt
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS. Importantly, mutant Wrn(Deltahel/Deltahel) mice show abnormal increases in visceral fat deposition and fasting blood triglyceride levels followed by insulin resistance and high blood glucose levels. These mice also exhibit...
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