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Article

Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.

Annals of the New York Academy of Sciences - 1 Jun 2010

Lebel Michel, Massip Laurent, Garand Chantal, Thorin Eric

Abstract excerpt

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS. Importantly, mutant Wrn(Deltahel/Deltahel) mice show abnormal increases in visceral fat deposition and...

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Source

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Identifiers

PMID: 20536831
DOI: 10.1111/j.1749-6632.2010.05189.x
PMCID: PMC3693984

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20536831-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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