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Article

Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle.

Circulation - 3 May 2016

van der Bruggen Cathelijne E, Happé Chris M, Dorfmüller Peter, Trip Pia, Spruijt Onno A, Rol Nina, Hoevenaars Femke P, Houweling Arjan C, Girerd Barbara, Marcus Johannes T, Mercier Olaf, Humbert Marc, Handoko M Louis, van der Velden Jolanda, Vonk Noordegraaf Anton, Bogaard Harm Jan, Goumans Marie-José, de Man Frances S

Abstract excerpt

BACKGROUND: The effect of a mutation in the bone morphogenetic protein receptor 2 (BMPR2) gene on right ventricular (RV) pressure overload in patients with pulmonary arterial hypertension is unknown. Therefore, we investigated RV function in patients who have pulmonary arterial hypertension with and without the BMPR2 mutation by combining in vivo measurements with molecular and histological analysis of human RV...

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Source

Identifiers

PMID: 26984938
DOI: 10.1161/CIRCULATIONAHA.115.020696

Genes

BMPR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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