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Article

Salirasib in the Treatment of Pancreatic Cancer

8 Jun 2010

Abstract excerpt

The Ras family of genes is involved in the cellular regulation of proliferation, differentiation, cell adhesion and apoptosis. The K-ras gene is mutated in over 90% of pancreatic cancer cases. Salirasib (S-trans,trans-farnesylthiosalycilic acid [FTS]) is a synthetic small molecule that acts as a potent Ras inhibitor. It is a farnesylcysteine mimetic that selectively disrupts the association of active RAS proteins...

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Identifiers

PMID: 20528225
DOI: 10.2217/fon.10.71

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