Article
WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant.
The Journal of pharmacology and experimental therapeutics - 1 Sept 2010
Li Ting, Wang Jia, Wang Xiang, Yang Na, Chen Si-Meng, Tong Lin-Jiang, Yang Chun-Hao, Meng Ling-Hua, Ding Jian
Abstract excerpt
The phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway is often constitutively activated in various human cancers, providing validated targets for cancer therapy. Among a series of 5-cyano-6-morpholino-4-substituted-pyrimidine analogs designed and synthesized based on PI3K target,...
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