Article
Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid.
The American journal of clinical nutrition - 1 Jan 2015
Wade Kaitlin H, Forouhi Nita G, Cook Derek G, Johnson Paul, McConnachie Alex, Morris Richard W, Rodriguez Santiago, Ye Zheng, Ebrahim Shah, Padmanabhan Sandosh, Watt Graham, Bruckdorfer K Richard, Wareham Nick J, Whincup Peter H, Chanock Stephen, Sattar Naveed, Lawlor Debbie A, Davey Smith George, Timpson Nicholas J
Abstract excerpt
BACKGROUND: Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and reverse causation. OBJECTIVES: We assessed the relation between L-ascorbic acid and 10 cardiometabolic traits by using a single nucleotide polymorphism in the solute carrier family 23 member 1 (SLC23A1) gene...
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