Article
Distinct genomic alterations in prostate cancers in Chinese and Western populations suggest alternative pathways of prostate carcinogenesis.
Cancer research - 1 Jul 2010
Mao Xueying, Yu Yongwei, Boyd Lara K, Ren Guoping, Lin Dongmei, Chaplin Tracy, Kudahetti Sakunthala C, Stankiewicz Elzbieta, Xue Liyan, Beltran Luis, Gupta Manu, Oliver R Tim D, Lemoine Nick R, Berney Daniel M, Young Bryan D, Lu Yong-Jie
Abstract excerpt
Prostate cancer is significantly more common in Western men than in Asian men, but the basis for this difference remains unknown. Because genomic studies of Asian prostate cancer are very limited, we used a genome-wide approach to reveal the genomic alterations in Chinese prostate cancers. We found a significant reduction in the frequency of certain somatic genomic changes that are commonly found in Western...
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