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Article

Fibronectin-binding protein B variation in Staphylococcus aureus.

BMC microbiology - 1 Jun 2010

Burke Fiona M, McCormack Niamh, Rindi Simonetta, Speziale Pietro, Foster Timothy J

Abstract excerpt

BACKGROUND: Fibronectin binding proteins A and B (FnBPA and FnBPB) mediate adhesion of S. aureus to fibrinogen, elastin and fibronectin. We previously identified seven different isotypes of FnBPA based on divergence in the fibrinogen- and elastin-binding A domains. The variation created differences in antigenicity while ligand binding functions were retained. Here, FnBPB variation was examined in both human and...

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Identifiers

PMID: 20515471
DOI: 10.1186/1471-2180-10-160
PMCID: PMC2894786

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