Article
Short communication: activity of etravirine on different HIV type 1 subtypes: in vitro susceptibility in treatment-naive patients and week 48 pooled DUET study data.
AIDS research and human retroviruses - 1 Jun 2010
Vingerhoets Johan, Azijn Hilde, Tambuyzer Lotke, Dierynck Inge, De Meyer Sandra, Rimsky Laurence, Nijs Steven, De Smedt Goedele, de Béthune Marie-Pierre, Picchio Gaston
Abstract excerpt
Etravirine (ETR) has previously shown potent in vitro activity against different primary HIV-1 isolates and demonstrated durable efficacy in treatment-experienced, HIV-1-infected patients in the Phase III DUET studies. The antiviral activity and efficacy of ETR against HIV-1 subtypes B and non-B were further investigated. The effect of HIV-1 subtype on ETR fold change in EC(50) value (FC) was analyzed in HIV-1...
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