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Article

Stromal cell-derived factor-1 and hepatocyte growth factor guide axon projections to the extraocular muscles.

Developmental neurobiology - 1 Jul 2010

Lerner Oleg, Davenport Dominic, Patel Priya, Psatha Maria, Lieberam Ivo, Guthrie Sarah

Abstract excerpt

Vertebrate eye movements depend on the co-ordinated function of six extraocular muscles that are innervated by the oculomotor, trochlear, and abducens nerves. Here, we show that the diffusible factors, stromal cell-derived factor-1 (SDF-1) and hepatocyte growth factor (HGF), guide the development of these axon projections. SDF-1 is expressed in the mesenchyme around the oculomotor nerve exit point, and oculomotor...

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Source

Identifiers

PMID: 20506246
DOI: 10.1002/dneu.20796

Genes

HGF
CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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