Article
The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.
Human molecular genetics - 15 Aug 2010
Forlani Greta, Giarda Elisa, Ala Ugo, Di Cunto Ferdinando, Salani Monica, Tupler Rossella, Kilstrup-Nielsen Charlotte, Landsberger Nicoletta
Abstract excerpt
Rett syndrome is a severe neurodevelopmental disorder mainly caused by mutations in the transcriptional regulator MeCP2. Although there is no effective therapy for Rett syndrome, the recently discovered disease reversibility in mice suggests that there are therapeutic possibilities. Identification of MeCP2 targets or modifiers of the phenotype can facilitate the design of curative strategies. To identify possible...
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