Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions

26 May 2010

Abstract excerpt

BACKGROUND: Spinal cord neurons of ALS patients demonstrate reduced cytochrome oxidase histochemical activity, and ALS spinal cord tissues have increased mitochondrial DNA (mtDNA) point mutations and depleted mtDNA levels. It is presently unknown whether mtDNA abnormalities are present in single human ALS neurons. RESULTS: Using laser capture microdissection (LCM) we isolated several hundred individual anterior...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20504367
DOI: 10.1186/1750-1326-5-21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletionsPMID 20504367Read ↗

Mitochondrial DNA Depletion in Respiratory Chain–Deficient P arkinson Disease NeuronsSemantic proximity Read ↗

Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer's Disease HippocampiSemantic proximity Read ↗

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosisSemantic proximity Read ↗

Myoclonic epilepsy and ragged red fibers (MERRF) syndrome: selective vulnerability of CNS neurons does not correlate with the level of mitochondrial tRNAlys mutation in individual neuronal isolates.Semantic proximity Read ↗

Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletionsSemantic proximity Read ↗

Decreased mitochondrial DNA copy number in nerve cells and the hippocampus during nicotine exposure is mediated by autophagySemantic proximity Read ↗

Mitochondrial DNA and respiratory chain function in spinal cords of ALS patientsSemantic proximity Read ↗

Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.