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Article

Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells.

Molecular cancer therapeutics - 1 Jun 2010

Zhong Bin, Sallman David A, Gilvary Danielle L, Pernazza Daniele, Sahakian Eva, Fritz Dillon, Cheng Jin Q, Trougakos Ioannis, Wei Sheng, Djeu Julie Y

Abstract excerpt

Clusterin (CLU), in its cytoplasmic form, is abundant in many advanced cancers and has been established to be cytoprotective against chemotherapeutic agents including docetaxel. However, little is known of the mechanism of its induction. Here, we provide evidence that AKT plays a critical role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20501799
DOI: 10.1158/1535-7163.MCT-09-0880
PMCID: PMC3874868

Genes

CLU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20501799-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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