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Article

Characterization of the Interaction and Cross-Regulation of Three Mycobacterium tuberculosis RelBE Modules

17 May 2010

Abstract excerpt

RelBE represents a typical bacterial toxin-antitoxin (TA) system. Mycobacterium tuberculosis H37Rv, the pathogen responsible for human tuberculosis, contains three RelBE-like modules, RelBE, RelFG, and RelJK, which are at least partly expressed in human macrophages during infection. RelBE modules appear to be autoregulated in an atypical manner compared to other TA systems; however, the molecular mechanisms and...

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PMID: 20498855
DOI: 10.1371/journal.pone.0010672

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