Article
A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia.
Journal of visualized experiments : JoVE - 21 May 2010
Guyenet Stephan J, Furrer Stephanie A, Damian Vincent M, Baughan Travis D, La Spada Albert R, Garden Gwenn A
Abstract excerpt
We describe a protocol for the rapid and sensitive quantification of disease severity in mouse models of cerebella ataxia. It is derived from previously published phenotype assessments in several disease models, including spinocerebellar ataxias, Huntington s disease and spinobulbar muscular atrophy. Measures include hind limb clasping, ledge test, gait and kyphosis. Each measure is recorded on a scale of 0-3,...
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