Article
Paradigm for industrial strain improvement identifies sodium acetate tolerance loci in Zymomonas mobilis and Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010
Yang Shihui, Land Miriam L, Klingeman Dawn M, Pelletier Dale A, Lu Tse-Yuan S, Martin Stanton L, Guo Hao-Bo, Smith Jeremy C, Brown Steven D
Abstract excerpt
The application of systems biology tools holds promise for rational industrial microbial strain development. Here, we characterize a Zymomonas mobilis mutant (AcR) demonstrating sodium acetate tolerance that has potential importance in biofuel development. The genome changes associated with AcR are determined using microarray comparative genome sequencing (CGS) and 454-pyrosequencing. Sanger sequencing analysis...
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