Further Analysis of Marek's Disease Virus Horizontal Transmission Confirms That U L 44 (gC) and U L 13 Protein Kinase Activity Are Essential, while U S 2 Is Nonessential

Abstract excerpt

Marek's disease virus (MDV) causes a devastating disease in chickens characterized by the development of lymphoblastoid tumors in multiple organs and is transmitted from the skin of infected chickens. We have previously reported that the U(S)2, U(L)44 (glycoprotein C [gC]), and U(L)13 genes are essential for horizontal transmission of MDV in gain-of-function studies using an a priori spread-deficient virus that...

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