Article
The differential evolutionary dynamics of avian cytokine and TLR gene classes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2010
Downing Tim, Lloyd Andrew T, O'Farrelly Cliona, Bradley Daniel G
Abstract excerpt
The potential for investigating immune gene diversity has been greatly enhanced by recent advances in sequencing power. In this study, variation at two categories of avian immune genes with differing functional roles, pathogen detection and mediation of immune mechanisms, was examined using high-throughput sequencing. TLRs identify and alert the immune system by detecting molecular motifs that are conserved among...
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