Article
Transthyretin-related amyloidoses and the heart: a clinical overview.
Nature reviews. Cardiology - 1 Jul 2010
Rapezzi Claudio, Quarta Candida Cristina, Riva Letizia, Longhi Simone, Gallelli Ilaria, Lorenzini Massimiliano, Ciliberti Paolo, Biagini Elena, Salvi Fabrizio, Branzi Angelo
Abstract excerpt
A nonhereditary form of systemic amyloidosis associated with wild-type transthyretin causes heart involvement predominantly in elderly men (systemic senile amyloidosis, or SSA). However, hereditary transthyretin-related amyloidosis (ATTR) is the most frequent form of familial systemic amyloidosis, a group of severe diseases with variable neurological and organ involvement. ATTR remains a challenging and widely...
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