Article
Drug resistance mutations in HIV-infected patients in the Spanish drug resistance database failing tipranavir and darunavir therapy.
Antimicrobial agents and chemotherapy - 1 Jul 2010
Poveda Eva, Anta Lourdes, Blanco José Luis, Casado José Luis, Gutiérrez Félix, García Federico, Gómez-Sirvent Juan Luis, Iribarren José Antonio, Soriano Vincent, de Mendoza Carmen
Abstract excerpt
The presence of resistance mutations in patients failing tipranavir or darunavir was examined at the national drug resistance database of the Spanish AIDS Research Network. Although mutations emerging during tipranavir and darunavir failures differed considerably, cross-resistance was found in up to half of the patients tested. Interestingly, mutation 54L, which is associated with tipranavir hypersusceptibility,...
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