Article
Biomarkers in lung oncology.
Pulmonary pharmacology & therapeutics - 1 Dec 2010
Rosell Rafael, Vergnenegre Alain, Liu Baorui, Cobo Manuel, Massuti Bartomeu, Wei Jia, Molina Miguel Angel, Costa Carlota, Queralt Cristina, Taron Miquel
Abstract excerpt
The survival of advanced non-small-cell lung cancer patients is short in spite of advances in new combination chemotherapy regimens. The benefit of adding antiangiogenic drugs and/or EGFR inhibitors is unclear. For the vast majority of patients without EGFR mutations, treatment approaches based on customization should be pursued. BRCA1 is central to the repair of DNA damage and is an important modulator of the...
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