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Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma

13 May 2010

Abstract excerpt

Small non-coding RNAs, in particular microRNAs(miRNAs), regulate fine-tuning of gene expression and can act as oncogenes or tumor suppressor genes. Differential miRNA expression has been reported to be of functional relevance for tumor biology. Using next-generation sequencing, the unbiased and absolute quantification of the small RNA transcriptome is now feasible. Neuroblastoma(NB) is an embryonal tumor with...

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PMID: 20466808
DOI: 10.1093/nar/gkq342

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