HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients.

Abstract excerpt

The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125...

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• Share to DNA, Viral
• Share to env Gene Products, Human Immunodeficiency Virus