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Article

Requirements for catalysis in the Cre recombinase active site

12 May 2010

Abstract excerpt

Members of the tyrosine recombinase (YR) family of site-specific recombinases catalyze DNA rearrangements using phosphoryl transfer chemistry that is identical to that used by the type IB topoisomerases (TopIBs). To better understand the requirements for YR catalysis and the relationship between the YRs and the TopIBs, we have analyzed the in vivo and in vitro recombination activities of all substitutions of the...

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PMID: 20462863
DOI: 10.1093/nar/gkq384

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