Article
N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia.
Diabetes - 1 Aug 2010
Riedl Eva, Koeppel Hannes, Pfister Frederick, Peters Verena, Sauerhoefer Sibylle, Sternik Paula, Brinkkoetter Paul, Zentgraf Hanswalter, Navis Gerjan, Henning Robert H, Van Den Born Jacob, Bakker Stephan J L, Janssen Bart, van der Woude Fokko J, Yard Benito A
Abstract excerpt
OBJECTIVE: The (CTG)(n) polymorphism in the serum carnosinase (CN-1) gene affects CN-1 secretion. Since CN-1 is heavily glycosylated and glycosylation might influence protein secretion as well, we tested the role of N-glycosylation for CN-1 secretion and enzyme activity. We also tested whether CN-1 secretion is changed under hyperglycemic conditions. RESULTS: N-glycosylation of CN-1 was either inhibited by...
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