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MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients

6 May 2010

Abstract excerpt

BACKGROUND: MUC1 protein is highly expressed in lung cancer. The cytoplasmic domain of MUC1 (MUC1-CD) induces tumorigenesis and resistance to DNA-damaging agents. We characterized MUC1-CD-induced transcriptional changes and examined their significance in lung cancer patients. METHODS: Using DNA microarrays, we identified 254 genes that were differentially expressed in cell lines transformed by MUC1-CD compared to...

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PMID: 20459602
DOI: 10.1186/1755-8794-3-16

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