Article
Callus formation is associated with hyperproliferation and incomplete differentiation of keratinocytes, and increased expression of adhesion molecules.
The British journal of dermatology - 1 Sept 2010
Kim S H, Kim S, Choi H I, Choi Y J, Lee Y S, Sohn K C, Lee Y, Kim C D, Yoon T J, Lee J H, Lee Y H
Abstract excerpt
BACKGROUND: A callus is a local thickening of skin, characterized by accelerated keratinization and a reduced rate of desquamation. However, the mechanism of callus formation is not fully understood. OBJECTIVES: To evaluate the expression patterns, in callused skin, of genes that are implicated in keratinization and adhesion/desquamation. METHODS: Samples of skin from the dorsum of the foot (DF), centre of the...
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