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Article

Intra- and interhost evolutionary dynamics of equine influenza virus.

Journal of virology - 1 Jul 2010

Murcia Pablo R, Baillie Gregory J, Daly Janet, Elton Debra, Jervis Carley, Mumford Jennifer A, Newton Richard, Parrish Colin R, Hoelzer Karin, Dougan Gordon, Parkhill Julian, Lennard Nicola, Ormond Doug, Moule Sharon, Whitwham Andrew, McCauley John W, McKinley Trevelyan J, Holmes Edward C, Grenfell Bryan T, Wood James L N

Abstract excerpt

Determining the evolutionary basis of cross-species transmission and immune evasion is key to understanding the mechanisms that control the emergence of either new viruses or novel antigenic variants with pandemic potential. The hemagglutinin glycoprotein of influenza A viruses is a critical host range determinant and a major target of neutralizing antibodies. Equine influenza virus (EIV) is a significant...

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Identifiers

PMID: 20444896
DOI: 10.1128/JVI.00112-10
PMCID: PMC2898244

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