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Lentiviral Vector Gene Therapy: Effective and Safe?

1 May 2010

Abstract excerpt

Over the past decade, more than 30 patients with different immunodeficiency disorders have been treated successfully using murine leukemia virus (MLV)-based γ-retroviral vectors to transfer therapeutic genes to autologous hematopoietic cells.1,2,3 However, this approach has been complicated by adverse events caused by γ-retroviral vector integration into the target cell genome. Five cases of lymphoid leukemia...

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PMID: 20436489
DOI: 10.1038/mt.2010.70

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