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Article

Molecular pathways of frontotemporal lobar degeneration.

Annual review of neuroscience - 1 Jan 2010

Sleegers Kristel, Cruts Marc, Van Broeckhoven Christine

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition that predominantly affects behavior, social awareness, and language. It is characterized by extensive heterogeneity at the clinical, pathological, and genetic levels. Recognition of these levels of heterogeneity is important for proper disease management. The identification of progranulin and TDP-43 as key proteins in a significant...

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PMID: 20415586
DOI: 10.1146/annurev-neuro-060909-153144

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FUS

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