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Article

IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms.

Leukemia - 1 Jun 2010

Pardanani A, Lasho T L, Finke C M, Mai M, McClure R F, Tefferi A

Abstract excerpt

Bone marrow DNA was screened for isocitrate dehydrogenase (IDH) mutations in 200 patients with chronic (n=166) or blast (n=34) phase myeloproliferative neoplasms (MPN). Included among the former were 77 patients with primary myelofibrosis (PMF), 47 essential thrombocythemia and 38 polycythemia vera (PV). Nine IDH mutations (5 IDH1 and 4 IDH2) were detected; mutational frequencies were approximately 21% (7 of 34)...

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Source

Identifiers

PMID: 20410924
DOI: 10.1038/leu.2010.77

Genes

IDH1
IDH2
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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