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Article

Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency.

Molecular genetics and metabolism - 1 Jul 2010

Fukami Maki, Nagai Toshiro, Mochizuki Hiroshi, Muroya Koji, Yamada Gen, Takitani Kimitaka, Ogata Tsutomu

Abstract excerpt

CONTEXT: Cytochrome P450 oxidoreductase (POR) is an electron donor for all microsomal P450 enzymes including CYP26 involved in inactivation of all-trans retinoic acid (atRA). Although previous studies in Por knockout mice suggest that atRA accumulation is relevant to various posterior organ abnormalities, a systematic analysis has not been performed for anorectal and urinary anomalies in patients with POR...

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Source

Identifiers

PMID: 20409737
DOI: 10.1016/j.ymgme.2010.03.023

Genes

POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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