Article
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jun 2010
Timmons James A, Knudsen Steen, Rankinen Tuomo, Koch Lauren G, Sarzynski Mark, Jensen Thomas, Keller Pernille, Scheele Camilla, Vollaard Niels B J, Nielsen Søren, Akerström Thorbjörn, MacDougald Ormond A, Jansson Eva, Greenhaff Paul L, Tarnopolsky Mark A, van Loon Luc J C, Pedersen Bente K, Sundberg Carl Johan, Wahlestedt Claes, Britton Steven L, Bouchard Claude
Abstract excerpt
A low maximal oxygen consumption (VO2max) is a strong risk factor for premature mortality. Supervised endurance exercise training increases VO2max with a very wide range of effectiveness in humans. Discovering the DNA variants that contribute to this heterogeneity typically requires substantial sample sizes. In the present study, we first use RNA expression profiling to produce a molecular classifier that...
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