Article
Genetic variability in E6, E7 and L1 protein of HPV81 from HIV-1 positive women in Italy.
The new microbiologica - 1 Jan 2010
Minosse Claudia, Garbuglia Anna R, Lapa Daniele, Sias Catia, Zaniratti Maria S, Capobianchi Maria R
Abstract excerpt
The genetic variability of E6, E7 and L1 of HPV81 from HIV-1 positive women carrying multiple HPV infections was investigated by clonal analysis for E6 and E7. The range of maximal divergence from the prototype was 0.6%-2.6% for E6 and 1.0%-3.1% for E7. Compared to prototype HPV81, 13 and 10 mutations were identified in E6 and E7, respectively. In the pRB binding domain of E7, all HPV81 clones showed D21, as...
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