Article
Heritable sclerosing bone disorders: presentation and new molecular mechanisms.
Annals of the New York Academy of Sciences - 1 Mar 2010
de Vernejoul Marie-Christine, Kornak Uwe
Abstract excerpt
Sclerosing bone disorders can be subdivided according to their clinical presentation, the primarily affected cell type, and the cellular pathways. Osteoclast-rich osteopetrosis and related disorders have been related in most cases to mutations in genes required for osteoclast function. More recently, osteoclast-poor forms of osteopetrosis have been described as being connected to factors that govern osteoclast...
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