Article
Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing - 1 Aug 2010
Schrickel Jan Wilko, Stöckigt Florian, Krzyzak Wieslaw, Paulin Denise, Li Zhenlin, Lübkemeier Indra, Fleischmann Bernd, Sasse Philipp, Linhart Markus, Lewalter Thorsten, Nickenig Georg, Lickfett Lars, Schröder Rolf, Clemen Christoph Stephan
Abstract excerpt
PURPOSE: Desmin mutations in humans cause desmin-related cardiomyopathy, resulting in heart failure, atrial and ventricular arrhythmias, and sudden cardiac death. The intermediate filament desmin is strongly expressed in striated muscle cells and in Purkinje fibers of the ventricular conduction s...
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