Article
Combining metabolic fingerprinting and footprinting to understand the phenotypic response of HPV16 E6 expressing cervical carcinoma cells exposed to the HIV anti-viral drug lopinavir.
The Analyst - 1 Jun 2010
Kim Dong-Hyun, Jarvis Roger M, Xu Yun, Oliver Anthony W, Allwood J William, Hampson Lynne, Hampson Ian N, Goodacre Royston
Abstract excerpt
Recently, it has been reported that the anti-viral drug, lopinavir, which is currently used as a human immunodeficiency virus (HIV) protease inhibitor, could also inhibit E6-mediated proteasomal degradation of mutant p53 in E6-transfected C33A cells. In this study, C33A parent control cells and HPV16 E6-transfected cells were exposed to lopinavir at concentrations ranging from 0 to 30 microM. The phenotypic...
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