Article
Severe bleeding in a woman heterozygous for the fibrinogen gammaR275C mutation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jul 2010
Rein Chantelle M, Anderson Brian L, Ballard Morgan M, Domes Christopher M, Johnston Joshua M, Madsen Russell Jared, Wolper Kathryn K M, Terker Andrew S, Strother John M, Deloughery Thomas G, Farrell David H
Abstract excerpt
The dysfibrinogen gammaR275C can be a clinically silent mutation, with only two out of 17 cases in the literature reporting a hemorrhagic presentation and four cases reporting a thrombotic presentation. We describe here a particularly severe presentation in 54-year-old female patient who required a hysterectomy at 47 years of age due to heavy menstrual bleeding. Coagulation studies revealed a prolonged...
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