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Article

Defective fibrinogen polymerization associated with a novel gamma279Ala-->Asp mutation.

British journal of haematology - 1 Feb 2000

Brennan S O, Wyatt J M, Ockelford P, George P M

Abstract excerpt

A woman with menorrhagia was investigated for a suspected fibrinogen mutation when coagulation tests revealed prolonged thrombin (55 s) and reptilase (43 s) times together with a functional and an antigenic fibrinogen concentration of 0.7 and 2.8 mg/ml respectively. Heterozygosity for a gamma-chain mutation was suggested by a doublet gamma band on SDS-PAGE and an increased negative charge was observed on...

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PMID: 10691848
DOI: 10.1046/j.1365-2141.2000.01859.x

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SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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