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Article

Perineural Invasion: Correlation With Aggressive Phenotype and Independent Prognostic Variable in Both Colon and Rectum Cancer

13 Apr 2010

Abstract excerpt

Liebig et al 1 reported on the clinical significance of perineural invasion (PNI), defined as tumor invasion of nerve structures and spread along nerve sheaths, in colorectal cancer. The authors observed PNI in 30% of rectum and 19% of colon cancers, respectively. In their cohort of 249 patients, presence of PNI was significantly associated with high tumor stage and grade as well as incidence of metastatic...

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Identifiers

PMID: 20385977
DOI: 10.1200/jco.2009.27.3581

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